Tetrapyrroles and derivatives
Abcam SB 216641 hydrochloride, h5-HT1B antagonist, 10MG
MW 523.03 g/mol, Purity >98%. Selective h5-HT₁B receptor antagonist. 25-fold selectivity over h5-HT₁D. Little or no affinity for a range of other receptor subtypes.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168568 dihydrochloride, D4 antagonist, 50MG
MW 422.4 g/mol, Purity >99%. Potent and selective D₄ antagonist (Ki = 8.8 nM at D₄, and 1842 nM at D₂). Inhibits amphetamine stimulated locomotor activity in vivo; orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GBR 12909 dihydrochloride, Dopamine transport inhibitor, 10MG
MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC₅₀ = 2.32 μM in rat hippocampal slices; IC₅₀ = 6-35 μM in whole cell patch clamp recordings).
The product is subject to the following: Abcam Restricted Use Statement
Abcam (S)-(-)-Raclopride, D2 receptor antagonist, 50MG
MW 347.24 g/mol, Purity >97%. High affinity (Kd = 1.2 nM) and high selectivity for D₂ receptors in vitro and in vivo (IC₅₀ = 32 nM). Centrally active following systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 206553 hydrochloride, 5-HT2B and 5-HT2C receptor antagonist, 50MG
MW 292.33 Da, Purity >99%. Potent and selective 5-HT2B and 5-HT2C serotonin receptor antagonist (pKi values are 7.92 (5-HT2C), 5.78 (5-HT2A), 7.65 (5-HT2B), 1A), 1D), 1E) and 1F). Centrally active following oral administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PNU 282987, alpha7 nAChR agonist, 10MG
MW 301.2 Da, Purity >99%. Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT₃ receptors (IC₅₀ = 4541 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam L-cis-Diltiazem, cyclic nucleotide-gated channel blocker, 5MG
MW 451 Da, Purity >97%. Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam EMD 386088 hydrochloride, 5-HT6 agonist, 10MG
MW 283.2 Da, Purity >98%. Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Prodigiosin, apoptotic agent, 250UG
MW 323.4 Da, Purity >95%. Potent apoptotic agent. Antibiotic agent. Induces caspase-dependent apoptosis. Inhibits mTORC1 and mTORC2. Reactivates p53. Inhibits iNOS expression. Shows anti-ischemic and antimalarial effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam Flupirtine maleate, Neuronal potassium channel opener, 25MG
MW 420.4 Da, Purity >99%. Neuronal potassium channel opener. Activates Kv7.2 channels and potently activates the inwardly rectifying potassium current (KIR; EC₅₀ = 600 nM). Centrally acting, non-opiate analgesic. Neuroprotective and antiapoptotic agent. Also has muscle relaxant properties. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Amylin (human), Endogenous peptide, 2500UG
MW 3903.3 Da, Purity >95%. Amylin (human), Endogenous peptide. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam QNZ, NF-kB inhibitor, 1MG
MW 358.4 Da, Purity >98%. Potent, selective NF-kB inhibitor (IC₅₀ = 11 nM). Inhibits LPS-induced TNFα production (IC₅₀ = 7 nM). Reduces edema in inflammation in vivo..
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB-3CT, MMP-2 and MMP-9 inhibitor, 1MG
MW 306.4 Da, Purity >98%. Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (Ki values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (Ki values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam HTMT (Histamine trifluoromethyl toluidide) dimaleate, H1/H2 receptor agonist, 50MG
MW 628.6 Da, Purity >99%. H1/H2 receptor agonist (Ki = 1.2 µM). More potent than histamine (ab120734). Activates IP3/Ca2+ signaling and induces proliferation of small cholangiocytes. Active *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GR 125743, 5-HT1B/1D antagonist.
GR 125743, 5-HT1B/1D antagonist.
The product is subject to the following: Abcam Restricted Use Statement